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The feasibility of malaria elimination in South Africa

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We do not source products. Our platform features offers from merchants who have signed up with PriceCheck. You are welcome to search for the product on our website and make contact with any of the merchants featured on PriceCheck for more information regarding their offers. Uthaipibull, C. Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum.

History of malaria - Wikipedia

Conway, D. A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses. Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 MSP Proteolytic processing of the Plasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains.

Intranasal immunization with yeast-expressed 19 kD carboxyl terminal fragment of Plasmodium yoelii merozoite surface protein-1 yMSP1 19 induces protective immunity to blood stage malaria infection in mice. Rotman, H. Fc receptors are not required for antibody-mediated protection against lethal malaria challenge in a mouse model. Vukovic, P.

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Oeuvray, C. Cytophilic immunoglobulin responses to Plasmodium falciparum glutamate-rich protein are correlated with protection against clinical malaria in Dielmo, Senegal. Druilhe, P.

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  • Mechanisms of defence against P. Freeman, R. Definition of T cell epitopes within the 19 kDa carboxyl terminal fragment of Plasmodium yoelii merozoite surface protein 1 MSP1 and their role in immunity to malaria. Absolute requirement for an active immune response involving B cells and T H cells in immunity to Plasmodium yoelii passively acquired with antibodies to the 19 kDa carboxyl terminal fragment of merozoite surface protein Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen PfMSP1 of Plasmodium falciparum are associated with reduced malaria morbidity.

    Branch, O. A longitudinal investigation of IgG and IgM antibody responses to the merozoite surface protein-1 kiloDalton domain of Plasmodium falciparum in pregnant women and infants: associations with febrile illness, parasitemia, and anemia. Human antibodies to the 19 kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro.

    Dodoo, D. Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria. Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection. O'Donnell, R. Antibodies against merozoite surface protein MSP -1 19 are a major component of the invasion-inhibitory response in individuals immune to malaria. Stoute, J. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria.

    Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. Boyle, J. Strategies for improving responses to DNA vaccines. By targeting antigen-presenting cells, DNA vaccines can induce far greater antibody responses. This might be crucial to developing successful vaccines against organisms such as malaria. Shi, Y. Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine.

    Development, expression, and murine testing of a multistage Plasmodium falciparum malaria vaccine candidate. Wang, R. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Engers, H. Malaria vaccine development: current status. Today 14 , 56—64 James, S. Malaria vaccine development: Status report, Grun, J.

    Antibody-independent immunity to reinfection malaria in B-cell-deficient mice. The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse. Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. Brake, D. Adoptive protection against Plasmodium chabaudi adami malaria in athymic nude mice by a cloned T cell line. Taylor-Robinson, A.


    The role of T H 1 and T H 2 cells in a rodent malaria infection. Indicates that T H 1- and T H 2-type T cells can control malaria infections through different mechanisms. Prolonged T H 1-like response generated by a Plasmodium yoelii -specific T cell clone allows complete clearance of infection in reconstituted mice. Stevenson, M. Favila-Castillo, L.

    Towards a blood-stage vaccine for malaria: are we following all the leads?

    Protection of rats against malaria by a transplanted immune spleen. Su, Z. Luty, A. Urban, B.

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    Plasmodium falciparum -infected erythrocytes modulate the maturation of dendritic cells. Nature , 73—77 Indicates that the maturation of dendritic cells might be impeded by parasitized RBCs, therefore dampening a developing T-cell response to the parasite. Seixas, E. Nguyen-Dinh, P. Absence of association between Plasmodium falciparum malaria and human immunodeficiency virus infection in children in Kinshasa, Zaire.

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